Basic Information
VIS ID
TVIS44016250
Fusion event
HTLV-1-STIM2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
26868607/26866985 (Hg38)
End
26868607/26866985 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
STIM2
miRNAs that regulate target gene
hsa-mir-877-3p ; hsa-mir-1185-1-3p ; hsa-mir-1185-2-3p
Nearest miRNA
hsa-mir-12113/Upstream/2346695; hsa-mir-1243/Downstream/1952597;
Nearest TSS
ENST00000502981/Upstream/5526; ENST00000477474/Downstream/136015;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/5369, chr4-CpG: 55/Downstream/3411114
Upstream sequence
TTTGAACTTTCAGAGTGTTTTGTTAATAAACTCTTGAAGTTGCAAATCTATATCCTGTCATTAGGAGGTGAGAGGCATTGTGGTTTTTGAAGATGGGGGT
Downstream sequence
GACATGTCCTTTGTGTTTGAGAAAGCTAATTCTGGGTGGATGGCAATGAGGAGATAACAGAGATAAGGATATCAGTTAGGAAACTATTTAGAAGGAGAGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate