Basic Information
VIS ID
TVIS44016251
Fusion event
HTLV-1-chr4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
28367285/28365663 (Hg38)
End
28367285/28365663 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
LOC105374557 ; LOC107986268
Nearest miRNA
hsa-mir-12113/Upstream/3845373; hsa-mir-1243/Downstream/453919;
Nearest TSS
ENST00000502981/Upstream/380600; ENST00000509416/Downstream/37038;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1504047, chr4-CpG: 55/Downstream/1912436
Nearby gene
MIR4275(+453919) ;
Upstream sequence
tccaaatGCATGTATTTTTTTCCTTTTAATTTTGGGAACATTATTTTTCTCACAAATAGAAAATAATTATTTGCTTGCTTACAGAATAGTTTTAGAGGCT
Downstream sequence
CTATGTAATTTAGTACTAGTACTGTAAGGCAGGATTAAGTTGCATATAGATACAATTATATCTTAAAAGTTTACATGGTTTTTATAAAACATACAAATAg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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