Basic Information
VIS ID
TVIS44016261
Fusion event
HTLV-1-KLF3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p14
Reference genome
GRCh37/hg19
Start
38698607/38696986 (Hg38)
End
38698607/38696986 (Hg38)
Orient
-
Location type
Intronic
Target gene
KLF3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-98-5p ; hsa-mir-23a-3p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-106b-5p ; hsa-mir-302a-3p ; hsa-mir-302b-3p ; hsa-mir-302c-3p ; hsa-mir-302d-3p ; hsa-mir-372-3p ; hsa-mir-373-3p ; hsa-mir-338-5p ; hsa-mir-20b-5p ; hsa-mir-520e ; hsa-mir-520a-3p ; hsa-mir-526b-3p ; hsa-mir-520b ; hsa-mir-520c-3p ; hsa-mir-519d-3p ; hsa-mir-520d-3p ; hsa-mir-449c-3p ; hsa-mir-302e ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-218-2-3p ; hsa-mir-758-5p ; hsa-mir-6516-5p ; hsa-mir-3658 ; hsa-mir-4639-5p ; hsa-mir-6811-5p ; hsa-mir-6511b-5p ; hsa-mir-6792-5p ; hsa-mir-657 ; hsa-mir-3665 ; hsa-mir-4708-5p ; hsa-mir-299-5p ; hsa-mir-8086 ; hsa-mir-6870-3p
Nearest miRNA
hsa-mir-12113/Upstream/1454995; hsa-mir-1243/Downstream/171046;
Nearest TSS
ENST00000502981/Upstream/32642; ENST00000510213/Downstream/79210;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/8002, chr4-CpG: 68/Downstream/170557
Upstream sequence
GCAGAGAGCCAATGAAACATTACGGTATTAGTTCATTTTCTTCTTGCTTGTCTTGCAGTAGTTTATAATGCACTGTGTTATTGAAGAACAAATGTATGAA
Downstream sequence
CATATCTTGGAAATAATATTTGTCAAGCATTAACTCAAAGATCTTTACTACCTTTACAGAAAAAAAAAATAGCTCTTTTCTTTTTCCTTTTGCAGGAGAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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