Basic Information
VIS ID
TVIS44016276
Fusion event
HTLV-1-NIPAL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p12
Reference genome
GRCh37/hg19
Start
48035530/48033513 (Hg38)
End
48035530/48033513 (Hg38)
Orient
+
Location type
Intronic
Target gene
NIPAL1
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-331-3p ; hsa-mir-6807-5p ; hsa-mir-4252 ; hsa-mir-3130-3p ; hsa-mir-1273g-3p ; hsa-mir-3934-5p ; hsa-mir-500b-3p ; hsa-mir-3613-3p ; hsa-mir-4482-5p ; hsa-mir-3130-5p ; hsa-mir-552-3p ; hsa-mir-6878-3p ; hsa-mir-6744-3p ; hsa-mir-4757-5p ; hsa-mir-6778-3p ; hsa-mir-150-5p ; hsa-mir-212-5p ; hsa-mir-4485-5p ; hsa-mir-186-3p ; hsa-mir-548av-3p ; hsa-mir-8057 ; hsa-mir-4284 ; hsa-mir-24-3p ; hsa-mir-210-5p ; hsa-mir-4749-3p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-4772-3p ; hsa-mir-1304-3p ; hsa-mir-4667-3p ; hsa-mir-6887-3p ; hsa-mir-6890-3p
Nearest miRNA
hsa-mir-12113/Upstream/380770; hsa-mir-1243/Downstream/4679169;
Nearest TSS
ENST00000502981/Upstream/8386; ENST00000506375/Downstream/46553;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/16091, chr4-CpG: 49/Downstream/235832
Upstream sequence
AGTTTGATTTCCTACTAACATAAATGTGTTTTACATTTGTAACACTGCAATGAAGCATAGAAGATTTTTTAAATCTCTCATCAGAACAAATTGCCAGAGT
Downstream sequence
CCTGTCAATTATTTTCCTCATCATAGTGGTTAATGACCATAGTTATCAGAGGACTTTTACAAGCATGGTGTTTTGGTTAAATTTTAACTCTCACTACAAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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