Basic Information
VIS ID
TVIS44016297
Fusion event
HTLV-1-JAKMIP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
6046780/6045053 (Hg38)
End
6046780/6045053 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4A
Target gene
JAKMIP1
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-378d-1/Upstream/121725; hsa-mir-12113/Downstream/1265397;
Nearest TSS
ENST00000502981/Upstream/26546; ENST00000507424/Downstream/25109;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/36495, chr4-CpG: 58/Downstream/60350
Upstream sequence
GAGTCCACTCACAGGGAGGTGCTGATGAACTGAGCAGCCTCATGGGGGCAGCATGCTGCAGGGTGGGGGCTGCTCTCCGCGCCCCGCCTCCCAGGGCCCC
Downstream sequence
TCAGGTGCAGAGCCTGGATCCCCTGCAACTGGTGGGGCTCATCTCTCCTCCCTCCCTTTGGGGATGGTCCCAAGGCTTCGACTCACGGCCAACtattaga
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate