Basic Information
VIS ID
TVIS44016300
Fusion event
HTLV-1-ADGRL3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
62395527/61529809 (Hg38)
End
62395527/61529809 (Hg38)
Orient
+
Location type
Intronic
Target gene
ADGRL3
miRNAs that regulate target gene
hsa-mir-20a-5p
Nearest miRNA
hsa-mir-12113/Upstream/607125; hsa-mir-1243/Downstream/4747015;
Nearest TSS
ENST00000502981/Upstream/32515; ENST00000509089/Downstream/57559;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/326726, chr4-CpG: 60/Downstream/1819320
Upstream sequence
CTATTCAAGACCAGTTTTTTTTTTCATTACAAATGGTTCTAAATGCAAGTTTAGCATAAATGTATGCATTAACTGCTTTGAAATGTGCAAAATTAAAGTT
Downstream sequence
TTAATTGACACTTGGGACAAAATATTTAAGACATTATGACCATAGATTTAAAAGTAAAGAAACTAAAAGTGCTTTTATTAATTTCTTTAGAATTGAATAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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