Basic Information
VIS ID
TVIS44016309
Fusion event
HTLV-1-TBC1D14 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
6940759/6939032 (Hg38)
End
6940759/6939032 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4A
Target gene
TBC1D14
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-320a ; hsa-mir-16-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-149-5p ; hsa-mir-24-3p ; hsa-mir-4252 ; hsa-mir-4268 ; hsa-mir-4284 ; hsa-mir-4448 ; hsa-mir-6772-3p ; hsa-mir-892b
Nearest miRNA
hsa-mir-378d-1/Upstream/1015704; hsa-mir-12113/Downstream/371418;
Nearest TSS
ENST00000502981/Upstream/28784; ENST00000467966/Downstream/15188;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/15168, chr4-CpG: 94/Downstream/47546
Upstream sequence
TGGTTGTGCAGTAGTGCAGCAGCGGCGCCATCCCCCAGGCTCTGTGGGCTGGCCTGAGTGCTGCATGGGAAAGCACCGTGGACACCATGGGGAAGAGATG
Downstream sequence
CTAGTGAAACCCTCTCCGGCTCAGCCGGTGGCCTCTTCCTCATCAGCAGTGGACGGCAtcctggctctgccacccactccctctgcatctggggcaagtc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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