Basic Information
VIS ID
TVIS44016312
Fusion event
HTLV-1-SLC4A4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
72135391/71269674 (Hg38)
End
72135391/71269674 (Hg38)
Orient
-
Location type
Intronic
Target gene
SLC4A4
miRNAs that regulate target gene
hsa-mir-5585-3p ; hsa-mir-498 ; hsa-mir-4279 ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-6778-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-660-3p ; hsa-mir-6829-3p ; hsa-mir-6791-3p
Nearest miRNA
hsa-mir-12113/Upstream/4992746; hsa-mir-1243/Downstream/5303894;
Nearest TSS
ENST00000502981/Upstream/14456; ENST00000512686/Downstream/69379;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/81922, chr4-CpG: 30/Downstream/762173
Upstream sequence
CGTGTCTTTGCCTAGCAAGTAGTTGGTGTTAGGAAATGTGCATGGACTTAAGTGGGaacacataacatttgtcatgtactatagacttaataaaggctgt
Downstream sequence
catgtccatgattatgtttaatcctcgtaagaaccttgtgagaaatataatgccagtgttatttttcccatattttacaaatgaagaaaGCAAAATTTGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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