Basic Information
VIS ID
TVIS44016318
Fusion event
HTLV-1-ODAPH integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
76481603/75556393 (Hg38)
End
76481603/75556393 (Hg38)
Orient
+
Location type
Intronic
Target gene
ODAPH
miRNAs that regulate target gene
hsa-mir-6516-3p ; hsa-mir-6740-3p ; hsa-mir-186-3p ; hsa-mir-4793-5p ; hsa-mir-5196-3p ; hsa-mir-6507-3p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-95-5p ; hsa-mir-29a-3p ; hsa-mir-29b-3p ; hsa-mir-29c-3p ; hsa-mir-3065-3p ; hsa-mir-4524a-3p ; hsa-mir-4537 ; hsa-mir-455-3p ; hsa-mir-508-5p ; hsa-mir-6499-3p ; hsa-mir-6512-3p ; hsa-mir-6516-5p ; hsa-mir-661 ; hsa-mir-6720-5p ; hsa-mir-6742-3p ; hsa-mir-6849-3p ; hsa-mir-766-3p
Nearest miRNA
hsa-mir-12113/Upstream/9279465; hsa-mir-1243/Downstream/1017175;
Nearest TSS
ENST00000502981/Upstream/328; ENST00000512893/Downstream/40747;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/41600, chr4-CpG: 56/Downstream/73789
Upstream sequence
agttggattttgtcacctgaagaccttggtcctcgtctcagcaatagctctgtgactttagacacacttaaaatctctgagtatcagattcctcatatgt
Downstream sequence
gaagtgacaacattaacaatatccatcgttatggggtttgcaaggaccaaatgagctatcatctgtgaaaaactcttcaagctaaaaacactgtacaaat
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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