Basic Information
VIS ID
TVIS44016328
Fusion event
HTLV-1-ACOX3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
8392140/8390413 (Hg38)
End
8392140/8390413 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4A
Target gene
ACOX3
Nearest miRNA
hsa-mir-378d-1/Upstream/385032; hsa-mir-12113/Downstream/1165755;
Nearest TSS
ENST00000502981/Upstream/16246; ENST00000532937/Downstream/4478;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/3469, chr4-CpG: 40/Downstream/37963
Upstream sequence
agcctccgggacagggcaagactctgaccaaaaaaaaaaaaGCCCTGAACTCAGCTTGACCAGACACAAAGAACTGCCACCTGTGCTTCATATCCCACCT
Downstream sequence
CCAGCTCCTCACTGCTGTCAGCAAGCCCTGCAGAGCCTCCCCTGGCATGGGGTTGCTGATAGGAGGGAGCCATCTCAGCGAGCTGATGCCCCCAGGGCTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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