Basic Information
VIS ID
TVIS44016332
Fusion event
HTLV-1-MAPK10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
87004931/86083778 (Hg38)
End
87004931/86083778 (Hg38)
Orient
-
Location type
Intronic
Target gene
MAPK10
miRNAs that regulate target gene
hsa-mir-221-3p ; hsa-mir-574-5p ; hsa-mir-5572 ; hsa-mir-4260 ; hsa-mir-450a-2-3p ; hsa-mir-6855-5p ; hsa-mir-3170 ; hsa-mir-6819-5p ; hsa-mir-6812-5p ; hsa-mir-6737-5p ; hsa-mir-6867-5p ; hsa-mir-3650 ; hsa-mir-4455 ; hsa-mir-6747-5p ; hsa-mir-608 ; hsa-mir-4651 ; hsa-mir-4664-5p ; hsa-mir-342-5p ; hsa-mir-5002-5p ; hsa-mir-499a-5p ; hsa-mir-208b-3p ; hsa-mir-208a-3p ; hsa-mir-3152-3p ; hsa-mir-641 ; hsa-mir-3617-5p
Nearest miRNA
hsa-mir-12113/Upstream/361245; hsa-mir-1243/Downstream/458704;
Nearest TSS
ENST00000502981/Upstream/1434; ENST00000509322/Downstream/5771;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/607962, chr4-CpG: 77/Downstream/510252
Nearest cancer related gene
MAPK10(TSG, No orient, 0)
Upstream sequence
tggacttttggggcatgtgacctactgagataccagccagggcagctaagggggtgctggcatcacccctcctctacccccatggtgcatagctcatggc
Downstream sequence
tccaaaagagacctcttccatccacatgaggagaggaaaggaaagagtgaaaagaactttgtcttgcattttggatatcagctcaaccacagtaggctag
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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