Basic Information
VIS ID
TVIS44016366
Fusion event
HTLV-1-KCNN2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
113749211/114413514 (Hg38)
End
113749211/114413514 (Hg38)
Orient
+
Location type
Intronic
Target gene
KCNN2
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-10397/Upstream/3899599; hsa-mir-103a-1/Downstream/1842229;
Nearest TSS
ENST00000502646/Upstream/50407; ENST00000505491/Downstream/20016;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/50016, chr5-CpG: 160/Downstream/755606
Upstream sequence
gctgggactacaggtgcccgccaccatgcctggctaattttttatgtatttttagtagaaatggggtttcaccatgttggccaggctggtcttgaattct
Downstream sequence
tgacctcaggtgatttgcccactaggcctctcaaagtgctgggattacaggcgtgagccaccacacctggccTTGTTTTTATTTTTTAACTCTTTTTGGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate