Basic Information
VIS ID
TVIS44016368
Fusion event
HTLV-1-AP3S1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
115191115/115855418 (Hg38)
End
115191115/115855418 (Hg38)
Orient
+
Location type
Intronic
Target gene
AP3S1
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-877-5p ; hsa-mir-30c-2-3p ; hsa-mir-18a-3p
Nearest miRNA
hsa-mir-10397/Upstream/5341503; hsa-mir-103a-1/Downstream/400325;
Nearest TSS
ENST00000502646/Upstream/12931; ENST00000507436/Downstream/11243;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/12859, chr5-CpG: 33/Downstream/106492
Upstream sequence
gtgagccaccgtgcctagtcCTATTTTAATAtttttattcaaccagggcctcgctcagccacctaggctggagtccggtggtatatcacggctcactgca
Downstream sequence
gccttgatctccctgggctcaggtgatcctctaacctcagcctcctgagtaactgggactacaggcatgcatcaccatgcccagctaatttttgtatttt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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