Basic Information
VIS ID
TVIS44016374
Fusion event
HTLV-1-PLEKHG4B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
127021/126906 (Hg38)
End
127021/126906 (Hg38)
Orient
-
Location type
Intronic
Target gene
PLEKHG4B
miRNAs that regulate target gene
hsa-mir-1304-5p ; hsa-mir-6765-5p ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-3188 ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-2467-5p ; hsa-mir-3975 ; hsa-mir-769-5p ; hsa-mir-4786-5p ; hsa-mir-1265 ; hsa-mir-6753-5p ; hsa-mir-1911-3p ; hsa-mir-138-5p ; hsa-mir-6820-5p ; hsa-mir-4660 ; hsa-mir-7978 ; hsa-mir-1307-3p ; hsa-mir-1207-3p ; hsa-mir-6736-3p ; hsa-mir-6739-3p ; hsa-mir-4677-5p ; hsa-mir-7156-5p ; hsa-mir-4273 ; hsa-mir-1287-3p ; hsa-mir-642a-5p ; hsa-mir-4742-3p ; hsa-mir-4469 ; hsa-mir-2276-5p ; hsa-mir-6892-3p ; hsa-mir-449b-3p ; hsa-mir-7106-3p
Nearest miRNA
hsa-mir-10397/Downstream/935990;
Nearest TSS
ENST00000637938/Upstream/34755; ENST00000502646/Downstream/13352;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/34284, chr5-CpG: 133/Downstream/37689
Upstream sequence
ggagaagaactcttactctcaagacagagaggggtgcccaaaagggaaatctggcctgcggcagagagcaccagattttataggcaggcttgaggaggtg
Downstream sequence
gtattccatttacatggggcccacagattggttggaccaggtgtgacatttacatagtgtgcgggtcggggaagctggccaccccaccctaatcttatgc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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