Basic Information
VIS ID
TVIS44016380
Fusion event
HTLV-1-ACSL6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
131291743/131956050 (Hg38)
End
131291743/131956050 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5C
Target gene
ACSL6
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-580-3p ; hsa-mir-526b-5p ; hsa-mir-431-5p ; hsa-mir-539-5p ; hsa-mir-4277 ; hsa-mir-5584-3p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-629-3p ; hsa-mir-670-3p ; hsa-mir-6867-3p ; hsa-mir-4713-5p ; hsa-mir-942-5p ; hsa-mir-4682 ; hsa-mir-4653-5p ; hsa-mir-2116-3p ; hsa-mir-3921 ; hsa-mir-532-3p ; hsa-mir-150-5p ; hsa-mir-6814-5p ; hsa-mir-4714-5p ; hsa-mir-618 ; hsa-mir-4524b-3p ; hsa-mir-1206 ; hsa-mir-4284 ; hsa-mir-6778-3p ; hsa-mir-2276-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-1304-3p ; hsa-mir-6741-3p ; hsa-mir-1281 ; hsa-mir-4485-5p ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-6890-3p
Nearest miRNA
hsa-mir-10397/Upstream/2558903; hsa-mir-103a-1/Downstream/261799;
Nearest TSS
ENST00000502646/Upstream/10352; ENST00000424244/Downstream/4895;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/10303, chr5-CpG: 80/Downstream/55149
Upstream sequence
GTAAGTACAAACCATCTATCCACCTTCTTTTGTTATTAAAATTAATAATATGCTTTTAAAAATGAGATACAAATGCCAAGATGTAATTTCTCAGTGTTGT
Downstream sequence
AGCCTGGGTTTCGGCTTGTCTGCATTCCTAACAGCATGTGGAGAACATTGTATAATTGGGACAAGAGTCTATGTTCAGTATGGGAACTTGGGGTGAGTAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate