Basic Information
VIS ID
TVIS44016388
Fusion event
HTLV-1-SLC6A3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
1394313/1394198 (Hg38)
End
1394313/1394198 (Hg38)
Orient
-
Location type
UTR3
Target gene
SLC6A3
miRNAs that regulate target gene
hsa-mir-137 ; hsa-mir-491-5p
Nearest miRNA
hsa-mir-4457/Upstream/84821; hsa-mir-10397/Downstream/116564;
Nearest TSS
ENST00000502646/Upstream/14131; ENST00000605200/Downstream/7109;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/7451, chr5-CpG: 16/Downstream/22479
Upstream sequence
TGGTGAGACATACCAGGACCCCCATCCTCCAATGCCTCTGAACAGACTGTGTGTGCAATGTGTCAACTGAACGCTCAATTTACGGCCTCTGCTGGGAGCC
Downstream sequence
ACGCATCGGGAAAGGACTTTGCATGAATTTGTGGTTTCCTCCATTTCACCTTCTGCACAGCTAAACCAAGCAGGACACTTGGCTTTTTAATATGGGCAAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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