Basic Information
VIS ID
TVIS44016403
Fusion event
HTLV-1-AFAP1L1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q32
Reference genome
GRCh37/hg19
Start
148697504/149317941 (Hg38)
End
148697504/149317941 (Hg38)
Orient
-
Location type
splicing
Target gene
AFAP1L1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-192-5p
Nearest miRNA
hsa-mir-10397/Upstream/255532; hsa-mir-103a-1/Downstream/110977;
Nearest TSS
ENST00000502646/Upstream/2301; ENST00000513661/Downstream/27489;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/45732, chr5-CpG: 41/Downstream/27384
Upstream sequence
ATCGCCCTGCAAGGCTGTGAGGTGGCCCCGGGCTTTGGGCCCCGACACCCATTTGCCTTCAGGATCCTGCGCAACCGGCAGGAGGTGGCCATCTTGGAGG
Downstream sequence
TGAGAGGAGAGGGTGGGACGTGGGTGGCTCTTGGTCTGGGGACTCTGGCCTGAGTGTCATGTTTTTGTTTGGGGGAGCCCTTGCTACTGACACCATGGGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate