Basic Information
VIS ID
TVIS44016408
Fusion event
HTLV-1-CYFIP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
156718290/157291281 (Hg38)
End
156718290/157291281 (Hg38)
Orient
+
Location type
Intronic
Target gene
CYFIP2
miRNAs that regulate target gene
hsa-mir-423-3p ; hsa-mir-149-5p ; hsa-mir-9-5p ; hsa-mir-3146 ; hsa-mir-335-3p ; hsa-mir-4729 ; hsa-mir-491-3p ; hsa-mir-5003-3p ; hsa-mir-5696 ; hsa-mir-579-3p ; hsa-mir-664b-3p
Nearest miRNA
hsa-mir-10397/Upstream/2461741; hsa-mir-103a-1/Downstream/3183121;
Nearest TSS
ENST00000502646/Upstream/14222; ENST00000518511/Downstream/9537;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/24542, chr5-CpG: 50/Downstream/168680
Upstream sequence
atggcttaggcatcaaattccccaggtgactctaatatacaacaagggttgaACACGAATGATTCAGGCCAACTCTTTACCTCCAAGTAAGGAAACTAAG
Downstream sequence
ACATTACAAGTTAAAAGGTGGGCCCAAGAagagtgaggaccagaactcaagtttcccaagaccccacccagggctctttccactgcaccatcctaacctc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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