Basic Information
VIS ID
TVIS44016426
Fusion event
HTLV-1-FAF2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q35.2
Reference genome
GRCh37/hg19
Start
175923755/176496754 (Hg38)
End
175923755/176496754 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5G
Target gene
FAF2
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-193b-3p ; hsa-mir-149-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p
Nearest miRNA
hsa-mir-10397/Upstream/128723; hsa-mir-1229/Downstream/132685;
Nearest TSS
ENST00000502646/Upstream/2732; ENST00000510124/Downstream/33054;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/48327, chr5-CpG: 135/Downstream/39743
Upstream sequence
CCTAGAAAGGTACAAGGGAGTTCCCTTCTGGAACAGAGAGAGACCAGTTGTAAATTTGGAGGGCTGACCTCTGGGGCTCTACCAATCCTGACTTCTTCTG
Downstream sequence
TGCATCAGGCCGCTATTAGCTTTTAGCTTTGCCCATTTATTGTCAAAATATTTACATACTTTGACCTAAATTACTCTATATCAGGTAATCTGTTCTTAGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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