Basic Information
VIS ID
TVIS44016439
Fusion event
HTLV-1-CDH12 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
21917305/21917196 (Hg38)
End
21917305/21917196 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5E
Target gene
CDH12
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-4455 ; hsa-mir-5010-3p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-8068 ; hsa-mir-6867-5p ; hsa-mir-574-5p ; hsa-mir-759 ; hsa-mir-4433a-5p ; hsa-mir-4433b-5p ; hsa-mir-4646-3p
Nearest miRNA
hsa-mir-10397/Upstream/4761204; hsa-mir-103a-1/Downstream/10018906;
Nearest TSS
ENST00000502646/Upstream/27349; ENST00000507674/Downstream/295292;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/457453, chr5-CpG: 68/Downstream/3273198
Upstream sequence
TTTTTCAGGTGTGGTTTAAGTACTGAACTCTCTGAACTTCAAGCTCCTCAATATACCAGTCATCTTTCCTAAGCTTCCCAAAGCCTTTCATTTGGCTTGA
Downstream sequence
GGGACATGGGGAGACAAAGACAAGAGCTGGCACGTGGCACCAATGggctctgacctggccgcatatgggaatcccctgggagcctcaaaaactcccaatg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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