Basic Information
VIS ID
TVIS44016466
Fusion event
HTLV-1-FYB1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
39257655/39257553 (Hg38)
End
39257655/39257553 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5A
Target gene
FYB1
miRNAs that regulate target gene
hsa-mir-4795-3p ; hsa-mir-613 ; hsa-mir-206 ; hsa-mir-1-3p ; hsa-mir-126-5p ; hsa-mir-4307 ; hsa-mir-656-3p ; hsa-mir-33a-3p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p
Nearest miRNA
hsa-mir-10397/Upstream/699992; hsa-mir-103a-1/Downstream/14693951;
Nearest TSS
ENST00000502646/Upstream/37947; ENST00000603514/Downstream/13087;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/182419, chr5-CpG: 39/Downstream/167237
Upstream sequence
TTTAGAaatattttgtgtagattttgctgtgtgacaggcattatgctgaagatattcacacataaacccatgcaactcttaaaataaacttaacaagtag
Downstream sequence
gtatagtgacttatcgctttttacatatggagaaattgaggcacagagaaggtaaattgtaatgagaagaactgaaatagaaatcaagggagtcaagctc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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