Basic Information
VIS ID
TVIS44016475
Fusion event
HTLV-1-EMB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
49713275/50417441 (Hg38)
End
49713275/50417441 (Hg38)
Orient
-
Location type
Intronic
Target gene
EMB
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-151a-3p ; hsa-mir-10a-5p ; hsa-mir-218-5p ; hsa-mir-6513-5p ; hsa-mir-5089-5p ; hsa-mir-6728-5p ; hsa-mir-769-3p ; hsa-mir-450b-3p ; hsa-mir-1296-5p ; hsa-mir-4425 ; hsa-mir-3147 ; hsa-mir-4468 ; hsa-mir-2861 ; hsa-mir-4781-3p ; hsa-mir-4512 ; hsa-mir-7160-3p ; hsa-mir-6895-5p ; hsa-mir-646 ; hsa-mir-576-3p ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p ; hsa-mir-5688 ; hsa-mir-495-3p ; hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-4796-5p ; hsa-mir-1250-3p ; hsa-mir-8084
Nearest miRNA
hsa-mir-10397/Upstream/11859880; hsa-mir-103a-1/Downstream/3534063;
Nearest TSS
ENST00000502646/Upstream/5443; ENST00000513414/Downstream/11286;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/4721033, chr5-CpG: 79/Downstream/23332
Upstream sequence
AAGAATAAAATTCTCAAAGTTTATATCCAAAATTTATAAAACATAATACTAATCCCTTGATTCTTGTAATTTCACTTCTCTCCCAAATAAGTCTCATATG
Downstream sequence
GATTGAAGAATCATGATGGTTTATTAAGTGATCCTATCAACAAGTTATTTACATGCCATCTGATTAGTGCCACACCAATGTGATACAGCCTAAAACACAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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