Basic Information
VIS ID
TVIS44016481
Fusion event
HTLV-1-ERCC8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
60231159/60935332 (Hg38)
End
60231159/60935332 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5H
Target gene
ERCC8
miRNAs that regulate target gene
hsa-mir-521 ; hsa-mir-26b-5p ; hsa-mir-1261 ; hsa-mir-4789-5p ; hsa-mir-563 ; hsa-mir-380-5p ; hsa-mir-4790-3p ; hsa-mir-7852-3p ; hsa-mir-758-5p ; hsa-mir-186-5p ; hsa-mir-3133 ; hsa-mir-6738-3p ; hsa-mir-544a ; hsa-mir-4653-3p ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-2276-3p ; hsa-mir-4645-3p ; hsa-mir-4772-3p ; hsa-mir-6514-5p ; hsa-mir-4802-5p ; hsa-mir-3688-3p ; hsa-mir-144-3p
Nearest miRNA
hsa-mir-10397/Upstream/1231629; hsa-mir-103a-1/Downstream/11234135;
Nearest TSS
ENST00000502646/Upstream/16719; ENST00000512623/Downstream/9627;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/90794, chr5-CpG: 56/Downstream/9620
Upstream sequence
gtagaggtcttttacctccctggctaggtatattcctaagtattttatttttcttttttgaagctattataaaaggggttgagtttttgatttgatcctc
Downstream sequence
agcttggtcactgttggtgtatagcagagctactgacttgtgtatgttaattttgtatcctgaaacttcgctgaattcatttaccagttctaggagcttt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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