Basic Information
VIS ID
TVIS44016483
Fusion event
HTLV-1-IPO11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
61754331/62458504 (Hg38)
End
61754331/62458504 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5H
Target gene
IPO11
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-let-7b-5p ; hsa-mir-629-3p ; hsa-mir-3679-3p ; hsa-mir-4279 ; hsa-mir-6832-3p ; hsa-mir-3119 ; hsa-mir-6756-3p ; hsa-mir-3127-3p
Nearest miRNA
hsa-mir-10397/Upstream/2754801; hsa-mir-103a-1/Downstream/9710963;
Nearest TSS
ENST00000502646/Upstream/8773; ENST00000507640/Downstream/8700;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/45275, chr5-CpG: 32/Downstream/1500713
Upstream sequence
attgtcctgcctcagcctcctgagtagctgggattacaggtgcatgccgctatgcccggctaatttttgtacttttagtagggacagggttttgccacat
Downstream sequence
tggccaggctggtctcaaacttctgacctcaaatgatctgcccgccttgacctcccgaagtgttaggattacaggcatgagccactgcgccccgccTATA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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