Basic Information
VIS ID
TVIS44016488
Fusion event
HTLV-1-ADAMTS6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
64457117/65161290 (Hg38)
End
64457117/65161290 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADAMTS6
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-221-3p
Nearest miRNA
hsa-mir-10397/Upstream/5457587; hsa-mir-103a-1/Downstream/7008177;
Nearest TSS
ENST00000502646/Upstream/140676; ENST00000508982/Downstream/37475;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/57901, chr5-CpG: 43/Downstream/401658
Upstream sequence
ccatacccagctagtttttaaattttttgtagagaaggtgtctccctatgttgcccaggctggtgtcaaactcctgggctcaagcaatcctctccccttg
Downstream sequence
gcctcccaaaatgttgagattgcaggcgtgagccaccgtgcccggccTCCTTGTCTCTTTTGAAATCTATGTTATCCGTCCATTCCATATCTCTATGGAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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