Basic Information
VIS ID
TVIS44016497
Fusion event
HTLV-1-ADCY2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p15.31
Reference genome
GRCh37/hg19
Start
7527822/7527709 (Hg38)
End
7527822/7527709 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADCY2
miRNAs that regulate target gene
hsa-mir-6833-5p ; hsa-mir-3190-3p ; hsa-mir-4680-5p ; hsa-mir-7114-5p ; hsa-mir-4539 ; hsa-mir-146a-3p ; hsa-mir-4714-5p ; hsa-mir-4318 ; hsa-mir-4643 ; hsa-mir-5698 ; hsa-mir-143-5p ; hsa-mir-6879-3p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6499-3p ; hsa-mir-215-3p ; hsa-mir-6773-3p ; hsa-mir-500b-3p ; hsa-mir-3922-5p
Nearest miRNA
hsa-mir-4277/Upstream/699788; hsa-mir-10397/Downstream/933216;
Nearest TSS
ENST00000502646/Upstream/113045; ENST00000513693/Downstream/83400;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/131162, chr5-CpG: 112/Downstream/322123
Upstream sequence
CTTATTGATTTTATAACAGGATTACTTATATGTTAGATAAATTTTATAGGATGTGTTTACACTGTGGATGCTTTAATATATTTAAGTTGTGATACAATTT
Downstream sequence
GAAAAATTTTAGATTGCACCTAATACAGCAAATCATCTATGCCAAGTGTGTAATCAATAGCAATGTGGATTTGTTATGTAACTGAGTCTTTTTAAGTATA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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