Basic Information
VIS ID
TVIS44016498
Fusion event
HTLV-1-WDR41 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
76792771/77496946 (Hg38)
End
76792771/77496946 (Hg38)
Orient
+
Location type
Intronic
Target gene
WDR41
miRNAs that regulate target gene
hsa-mir-491-3p ; hsa-mir-4662a-5p ; hsa-mir-6781-3p ; hsa-mir-2682-3p ; hsa-mir-4480 ; hsa-mir-3665 ; hsa-mir-600 ; hsa-mir-6872-3p ; hsa-mir-125a-3p ; hsa-mir-3972 ; hsa-mir-3194-5p ; hsa-mir-1202 ; hsa-mir-3185 ; hsa-mir-1253
Nearest miRNA
hsa-mir-10397/Upstream/4618283; hsa-mir-103a-1/Downstream/5343209;
Nearest TSS
ENST00000502646/Upstream/4350; ENST00000510030/Downstream/2690;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/4329, chr5-CpG: 60/Downstream/131116
Nearby gene
WDR41(-4439) ;
Upstream sequence
caactgtggaacttaccacgaagttaaagtaatagtactggcacaaggacagacatgtagaccaatggaatagaacagagagcctagagataaactctta
Downstream sequence
catatatggtcaatttttttgacaagtgtactaagaccatccaatggggaaaggacagtcttttcaacaattggtactaggaaaactggatctctacaca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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