Basic Information
VIS ID
TVIS44016503
Fusion event
HTLV-1-SERINC5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
79472885/80177062 (Hg38)
End
79472885/80177062 (Hg38)
Orient
-
Location type
Intronic
Target gene
SERINC5
miRNAs that regulate target gene
hsa-mir-145-5p ; hsa-mir-16-5p ; hsa-mir-3926 ; hsa-mir-4753-5p ; hsa-mir-6796-3p ; hsa-mir-4484 ; hsa-mir-6768-3p ; hsa-mir-548an ; hsa-mir-9-5p
Nearest miRNA
hsa-mir-10397/Upstream/7298399; hsa-mir-103a-1/Downstream/2663093;
Nearest TSS
ENST00000502646/Upstream/9882; ENST00000511881/Downstream/78136;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/141397, chr5-CpG: 103/Downstream/78488
Upstream sequence
AGATGCTTTTCCTGTCCCACTATCGCTGCAGCAGACATTTAGCTGCTGACAGCCCTGCGCTCCCTGTTGCTGGGTTTTCTGTGCAGTGCTTGGAAAGAAC
Downstream sequence
AAGGTCTCCCAGGCCAGCAGAGTATCAGAGTCCTCTTACACCCTACCTGGAAGTGGGATGCGGTGGTGAGAAGAGGGGAGGTAGATAGGCAATGATGGAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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