Basic Information
VIS ID
TVIS44016511
Fusion event
HTLV-1-MEF2C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
88096388/88800571 (Hg38)
End
88096388/88800571 (Hg38)
Orient
+
Location type
Intronic
Target gene
MEF2C
miRNAs that regulate target gene
hsa-mir-223-3p ; hsa-mir-21-5p ; hsa-mir-26b-5p ; hsa-mir-92a-3p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-mir-4668-5p ; hsa-mir-7844-5p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-23a-3p ; hsa-mir-214-3p ; hsa-mir-135b-5p ; hsa-mir-499a-3p
Nearest miRNA
hsa-mir-10397/Upstream/133632; hsa-mir-103a-1/Downstream/1216050;
Nearest TSS
ENST00000502646/Upstream/15029; ENST00000511876/Downstream/4046;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/110578, chr5-CpG: 38/Downstream/83478
Nearest cancer related gene
MEF2C(OG, No orient, 0)
Upstream sequence
GAGTGGAGCTTGCTAAATCATTGCTAAATGAAGCAATGGGCTGTAAGCATGTCCTGTGGGATCTGCATCTTCAGATCATCCTGAAGTACTCAACAACCAC
Downstream sequence
ATCTTCTTCCAGGAACAGAGCCCAACATAAACTGGTAGGGTTTGCTGTCTTAGACAGCTAAGAGAACGAGGAGTGGAGCTAGTGAACAAGCAGTGAAGGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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