Basic Information
VIS ID
TVIS44016518
Fusion event
HTLV-1-FAM172A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q15
Reference genome
GRCh37/hg19
Start
93289290/93953585 (Hg38)
End
93289290/93953585 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5B
Target gene
FAM172A
miRNAs that regulate target gene
hsa-mir-421 ; hsa-mir-330-3p ; hsa-mir-218-5p ; hsa-mir-1827 ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-6835-3p
Nearest miRNA
hsa-mir-10397/Upstream/332797; hsa-mir-103a-1/Downstream/2125553;
Nearest TSS
ENST00000502646/Upstream/71984; ENST00000508383/Downstream/121135;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/331951, chr5-CpG: 41/Downstream/157663
Nearest cancer related gene
FAM172A(TSG, No orient, 0)
Upstream sequence
tcttactttcccccagagtctcttccctttgtgcagagctgcctgagctgggggaagggtgacacaagtaccctgtggctgccaccagtggcactgcact
Downstream sequence
gggtcagacctgaagccagtatggtactacatctcacctacggcctgcagtaaccactgcctaactaccacctgtgtccactcaaggtactacggttcta
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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