Basic Information
VIS ID
TVIS44016519
Fusion event
HTLV-1-SEMA5A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p15.31
Reference genome
GRCh37/hg19
Start
9398570/9398458 (Hg38)
End
9398570/9398458 (Hg38)
Orient
+
Location type
Intronic
Target gene
SEMA5A
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-218-5p ; hsa-mir-6811-5p ; hsa-mir-6511b-5p ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-6836-5p ; hsa-mir-6132 ; hsa-mir-6754-5p ; hsa-mir-4441 ; hsa-mir-100-3p ; hsa-mir-4270 ; hsa-mir-4709-3p ; hsa-mir-4645-3p ; hsa-mir-3185 ; hsa-mir-144-3p ; hsa-mir-8077 ; hsa-mir-496 ; hsa-mir-216a-5p ; hsa-mir-548c-3p ; hsa-mir-4695-3p ; hsa-mir-4772-3p ; hsa-mir-6787-3p ; hsa-mir-1304-3p ; hsa-mir-660-3p ; hsa-mir-6736-3p ; hsa-mir-6890-3p ; hsa-mir-4714-3p
Nearest miRNA
hsa-mir-4277/Upstream/344563; hsa-mir-10397/Downstream/1003906;
Nearest TSS
ENST00000502646/Upstream/18257; ENST00000510879/Downstream/112875;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/940298, chr5-CpG: 138/Downstream/146122
Upstream sequence
TTCATTTATCTTGAGAGTTTCCCCCACATATCGTACTGAAGATAAAATACAATGAGATCATAACCCTTCAAAAGCGTAGCTTATTGTGCAATATTTTTCT
Downstream sequence
CCAGTGGTTAATGGTGATTCTCACAGATTGGAACAGAAAAGGTTATAGCAAGGGCCAGGTCTGCAAACACATTGAGAAAATAATTTCCTAACAGACAAGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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