Basic Information
VIS ID
TVIS44016522
Fusion event
HTLV-1-chr5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q15
Reference genome
GRCh37/hg19
Start
95019245/95683541 (Hg38)
End
95019245/95683541 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5B
Target gene
LOC105379090 ; SPATA9
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p
Nearest miRNA
hsa-mir-10397/Upstream/2062753; hsa-mir-103a-1/Downstream/395597;
Nearest TSS
ENST00000502646/Upstream/531; ENST00000515852/Downstream/15170;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/36551, chr5-CpG: 121/Downstream/47455
Nearby gene
SPATA9(-531) ;
Upstream sequence
ATGTCAGATGACCATTAGTTCCCCCGATCAAATATGGGAAGAACTTGATACCATGCAGACTTGATTGACTGCCTAGTTTTATATATATATAgtttgtttg
Downstream sequence
tttgtttgttttttgagatggagtcttgccctgttgcccaggctggagtgcagtggcgcgatcttggctcactgcaacctcagcctcccgggttcacacc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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