VISDB Viral Integration Site DataBase

VIS ID

TVIS44016540

Fusion event

HTLV-1-FOXO3 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Disease

HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

Quality evaluation

Normal

Reported year

2017

PubMed ID

Virus name

HTLV-1

Reference genome

Not given

Chromosome

chr6

Cytoband

q21

Reference genome

Start

End

108914588/108593385 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-222-3p ; hsa-mir-221-3p ; hsa-mir-182-5p ; hsa-mir-197-3p ; hsa-mir-155-5p ; hsa-mir-96-5p ; hsa-mir-23a-3p ; hsa-mir-9-5p ; hsa-mir-335-5p ; hsa-mir-744-5p ; hsa-mir-615-3p ; hsa-mir-26a-5p ; hsa-let-7c-5p ; hsa-mir-126-3p ; hsa-mir-29a-3p ; hsa-mir-21-5p ; hsa-mir-590-5p ; hsa-mir-548c-3p ; hsa-mir-126-5p ; hsa-mir-340-5p ; hsa-mir-621 ; hsa-mir-4714-3p ; hsa-mir-4795-5p ; hsa-mir-217 ; hsa-mir-548av-3p ; hsa-mir-671-5p ; hsa-mir-3622a-3p ; hsa-mir-3622b-3p ; hsa-mir-4786-3p ; hsa-mir-6079 ; hsa-mir-223-3p ; hsa-mir-218-5p ; hsa-mir-4795-3p ; hsa-mir-6069 ; hsa-mir-665 ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-1179 ; hsa-mir-6828-5p ; hsa-mir-1228-3p ; hsa-mir-6882-5p ; hsa-mir-4328 ; hsa-mir-4275 ; hsa-mir-100-3p ; hsa-mir-3927-5p ; hsa-mir-6832-3p ; hsa-mir-498 ; hsa-mir-4279 ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-5089-5p ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-592 ; hsa-mir-31-5p ; hsa-mir-93-5p ; hsa-mir-30c-5p

Nearest miRNA

hsa-mir-10398/Upstream/1809165; hsa-mir-1202/Downstream/10475662;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/31184, chr6-CpG: 18/Downstream/70176

Nearest cancer related gene

FOXO3(TSG, No orient, 0)

Upstream sequence

TGAGAAAAGGTTGTGTCAGGTTAATTGGGCTTAAGGAAAGCTAAATAATTGGTGGGAGAAGGAAAAGTAAATATTAATTTTTTCCTTTGCTGTGTAtttc

Downstream sequence

ttttttctttttttttttgagatggagtctcgctctggctggagtgcagtggcacgatcttagctcactgtaacctctgccacctgggttcaagtgattc