Basic Information
VIS ID
TVIS44016542
Fusion event
HTLV-1-METTL24 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q21
Reference genome
GRCh37/hg19
Start
110577617/110256414 (Hg38)
End
110577617/110256414 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6F
Target gene
METTL24
miRNAs that regulate target gene
hsa-mir-3189-5p ; hsa-mir-5699-5p ; hsa-mir-4758-3p ; hsa-mir-4480 ; hsa-mir-6889-3p ; hsa-mir-6884-3p ; hsa-mir-4717-3p ; hsa-mir-6868-3p ; hsa-mir-5007-3p ; hsa-mir-4778-3p ; hsa-mir-1248 ; hsa-mir-1237-3p
Nearest miRNA
hsa-mir-10398/Upstream/3472194; hsa-mir-1202/Downstream/8812633;
Nearest TSS
ENST00000381078/Upstream/32118; ENST00000569685/Downstream/101563;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/75796, chr6-CpG: 114/Downstream/101237
Upstream sequence
CCTGGTCATATAAGATATGAGTCCCAGTGCTGCAGTTAACCCCAGCACGACTCATGCTAGACCTGTCAGAGTCAACTTGATGTCCTCCATTTCTGAACCC
Downstream sequence
CATGCAGAGTTCTAGCAAAGTAGGTAGCATGGTCACTCTTGTGTTGATCTtttgatttccttacctgggctgtaagttcctttagggcaggaatctaact
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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