Basic Information
VIS ID
TVIS44016547
Fusion event
HTLV-1-GOPC integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
117906445/117585282 (Hg38)
End
117906445/117585282 (Hg38)
Orient
+
Location type
Intronic
Target gene
GOPC
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-103a-3p
Nearest miRNA
hsa-mir-10398/Upstream/10801062; hsa-mir-1202/Downstream/1483765;
Nearest TSS
ENST00000381078/Upstream/11711; ENST00000368494/Downstream/17082;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/36915, chr6-CpG: 55/Downstream/16911
Nearest cancer related gene
GOPC(OG, No orient, 0)
Upstream sequence
TTTTTATTCACAGTTTCCTATTAATCCACTTGCCTAAACTTTAATCCTCTACCTGTATTATTTTCTAAGAATACACAACAACTACACAATTTTCATTTTA
Downstream sequence
AATATAAGCAGGTTTTTATTTTTTTAACTGTCTTATGGATAAATACTCCAATTATTTTACCTTAAGCACCCCTCAAAAGCCTCATGTTTTGAAGGAGGAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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