Basic Information
VIS ID
TVIS44016549
Fusion event
HTLV-1-HIVEP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
12054919/12054686 (Hg38)
End
12054919/12054686 (Hg38)
Orient
+
Location type
Intronic
Target gene
HIVEP1
miRNAs that regulate target gene
hsa-mir-221-3p ; hsa-mir-98-5p ; hsa-mir-32-5p ; hsa-mir-23a-3p ; hsa-mir-363-3p ; hsa-mir-25-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-433-3p ; hsa-mir-92b-3p ; hsa-mir-1206 ; hsa-mir-7154-5p ; hsa-mir-595 ; hsa-mir-410-3p ; hsa-mir-3613-3p ; hsa-mir-190a-3p ; hsa-mir-3163 ; hsa-mir-548e-5p
Nearest miRNA
hsa-mir-3691/Upstream/1614892; hsa-mir-10398/Downstream/4086870;
Nearest TSS
ENST00000381078/Upstream/39099; ENST00000399469/Downstream/71060;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/41852, chr6-CpG: 44/Downstream/694959
Nearest cancer related gene
HIVEP1(TSG, No orient, 0)
Upstream sequence
tttcggtgtcattaaaattccctataaacatcagtttcaaatgactgcataatattgtatcacatgacttcaccataatgaactttttttgctgttatta
Downstream sequence
gtttgtttccattttatttggttatCGTGGAACCTCTTTTTTCACTTTTCTGATTAACATACATGATTTCATGACATAGCATATTATTTGATGTTGTGCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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