Basic Information
VIS ID
TVIS44016551
Fusion event
HTLV-1-FABP7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
123101012/122779867 (Hg38)
End
123101012/122779867 (Hg38)
Orient
+
Location type
Exonic
Target gene
FABP7
miRNAs that regulate target gene
hsa-mir-132-3p ; hsa-mir-223-3p ; hsa-mir-4697-3p ; hsa-mir-6823-3p ; hsa-mir-2114-3p ; hsa-mir-1224-3p ; hsa-mir-16-1-3p
Nearest miRNA
hsa-mir-10398/Upstream/2764610; hsa-mir-1202/Downstream/3704764;
Nearest TSS
ENST00000381078/Upstream/108; ENST00000487215/Downstream/9182;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/169307, chr6-CpG: 65/Downstream/9276
Upstream sequence
TGTCTCTAAAGAGGGGAAAGGGCAAGGATGGTGGAGGCTTTCTGTGCTACCTGGAAGCTGACCAACAGTCAGAACTTTGATGAGTACATGAAGGCTCTAG
Downstream sequence
GTAGGTAACAATAAGACCGGCTGTTCTCTTCTCAACGTGCAGctttagatatttgcagattccatttttcactcatcaggtcagcaagaggcaaagacag
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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