Basic Information
VIS ID
TVIS44016570
Fusion event
HTLV-1-PLAGL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
144350824/144029687 (Hg38)
End
144350824/144029687 (Hg38)
Orient
+
Location type
Intronic
Target gene
PLAGL1
miRNAs that regulate target gene
hsa-mir-98-5p
Nearest miRNA
hsa-mir-10398/Upstream/3345804; hsa-mir-1202/Downstream/7072988;
Nearest TSS
ENST00000381078/Upstream/20864; ENST00000367568/Downstream/34824;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/20977, chr6-CpG: 104/Downstream/34070
Nearest cancer related gene
PLAGL1(TSG, No orient, 0)
Upstream sequence
gctgagattttccacttatcagattggcaatgattcaaaaatcttaacacatactatgctgtcaagcatttggagaaaggcactctcatctctcacatat
Downstream sequence
tgctgatcggagtagaaactggtacagccttatggaaggcaaccttatggaagttgcctcacatattgctcacatattgctgatgggagtagaaactggt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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