Basic Information
VIS ID
TVIS44016572
Fusion event
HTLV-1-UTRN integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
145057793/144736657 (Hg38)
End
145057793/144736657 (Hg38)
Orient
+
Location type
Intronic
Target gene
UTRN
miRNAs that regulate target gene
hsa-mir-206 ; hsa-mir-1-3p ; hsa-mir-21-5p ; hsa-mir-455-3p ; hsa-mir-505-3p ; hsa-mir-484 ; hsa-mir-331-3p ; hsa-let-7b-5p ; hsa-mir-3136-3p ; hsa-mir-4313 ; hsa-mir-26a-2-3p ; hsa-mir-26a-1-3p ; hsa-mir-1915-5p ; hsa-mir-6793-3p ; hsa-mir-4714-3p ; hsa-mir-203b-5p ; hsa-mir-3691-3p ; hsa-mir-556-3p ; hsa-mir-6718-5p ; hsa-mir-6801-5p
Nearest miRNA
hsa-mir-10398/Upstream/4052774; hsa-mir-1202/Downstream/6366018;
Nearest TSS
ENST00000381078/Upstream/76813; ENST00000480333/Downstream/18057;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/449513, chr6-CpG: 132/Downstream/998103
Upstream sequence
TCCTCCATACCAATCTTATGCTAGGCCTATTTCAATATATTCTTAATTGGCATTTCTCCATTAACATAAATCCTAAAATGATAAACCTAAAGCACAAACC
Downstream sequence
TGGCATGAGGTTTCCTGGAGATAAAAACTGCCCGTAGTGCATGCCATGGGATCTGAGCTCCTCCACCTGGCACAGAAGGCTGCACAGCAATTTGTCCTCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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