Basic Information
VIS ID
TVIS44016588
Fusion event
HTLV-1-MAP3K4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q26
Reference genome
GRCh37/hg19
Start
161479122/161058090 (Hg38)
End
161479122/161058090 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6E
Target gene
MAP3K4
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-148a-3p ; hsa-mir-93-5p ; hsa-mir-92a-3p ; hsa-mir-199a-3p ; hsa-mir-199b-3p ; hsa-mir-1245a ; hsa-mir-3123 ; hsa-mir-3129-5p ; hsa-mir-3691-3p ; hsa-mir-6073 ; hsa-mir-8062 ; hsa-mir-8079 ; hsa-mir-144-3p ; hsa-mir-101-3p
Nearest miRNA
hsa-mir-10398/Upstream/2293337; hsa-mir-1913/Downstream/5451264;
Nearest TSS
ENST00000381078/Upstream/23732; ENST00000542851/Downstream/15239;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/65558, chr6-CpG: 76/Downstream/587795
Nearest cancer related gene
MAP3K4(TSG, No orient, 0)
Upstream sequence
GTGATAACAACAGCACAATAGTAATATTGAGAAGACTAGTAGCTAGCATTAACTGAACACTCGCTACATGccggggcaaggaagagggctaagtaacttg
Downstream sequence
atcaggtcacaaatctagaaagtggcagagccaggatatgaacccagagctctggctgtaaagccatgtatgctcttgacagtgtacAGTCTCCCAAAGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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