Basic Information
VIS ID
TVIS44016592
Fusion event
HTLV-1-PDE10A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q27
Reference genome
GRCh37/hg19
Start
165905570/165492082 (Hg38)
End
165905570/165492082 (Hg38)
Orient
+
Location type
Intronic
Target gene
PDE10A
miRNAs that regulate target gene
hsa-mir-1287-3p ; hsa-mir-190a-3p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-7151-5p ; hsa-mir-5681b ; hsa-mir-5579-5p ; hsa-mir-33a-3p
Nearest miRNA
hsa-mir-10398/Upstream/6727329; hsa-mir-1913/Downstream/1017272;
Nearest TSS
ENST00000381078/Upstream/182475; ENST00000435810/Downstream/169987;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/157601, chr6-CpG: 363/Downstream/168312
Upstream sequence
agagagaagatccaaataagctcaataagaaacaaacgggagctattacaaacaacaccacacaaatacaaaggatgattcaaggctactatgaacaccc
Downstream sequence
ttatgcacataaactgggaaatctagaggagatggataaattcctggaaacatacaaccctctaagataaaaccaggaataaacagaaactctgaacaga
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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