Basic Information
VIS ID
TVIS44016597
Fusion event
HTLV-1-WDR27 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q27
Reference genome
GRCh37/hg19
Start
170069279/169669183 (Hg38)
End
170069279/169669183 (Hg38)
Orient
-
Location type
Intronic
Target gene
WDR27
Nearest miRNA
hsa-mir-10398/Upstream/2671271; hsa-mir-4644/Downstream/661578;
Nearest TSS
ENST00000381078/Upstream/1908; ENST00000332290/Downstream/1510;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1100, chr6-CpG: 149/Downstream/32383
Upstream sequence
GAATAACATCATATCCTGAAAAATATTTAAGTTATTTCCTTTTGACATTTTATGTTGATTAAAAAGTGCCTTTTACCAGGAAATGCTCAGTATTCATTTG
Downstream sequence
AAATCTTTAAAATCAAATGGTATAAACTGTTGACTTGTTGAGTATGCTGTTAAAAGAATGTGAGCACTTCACGGACTCACGTGACAACCATTCCTCATGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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