Basic Information
VIS ID
TVIS44016600
Fusion event
HTLV-1-KDM1B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
18159038/18158807 (Hg38)
End
18159038/18158807 (Hg38)
Orient
+
Location type
Intronic
Target gene
KDM1B
miRNAs that regulate target gene
hsa-mir-373-3p ; hsa-mir-148b-3p ; hsa-mir-192-5p ; hsa-mir-215-5p
Nearest miRNA
hsa-mir-3691/Upstream/2017183; hsa-mir-10398/Downstream/412977;
Nearest TSS
ENST00000381078/Upstream/3355; ENST00000642162/Downstream/52688;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/2684, chr6-CpG: 131/Downstream/105101
Upstream sequence
GCTAAGCATTTTTCATTCCTTAATCTAATTGAAAAAAATTCTGTTAGCTCTTAATCTTTCATAGCTGCTACACATTATTTCTCTTGTAGACTTTGGTTCT
Downstream sequence
TAATATATGTTTAACCATGCTGTTATTGGACTAGTTTGGGAAATTTTTTCCAGTAGAAGATACCAGTGCTTCTATCTAATTTAGATCTGTATATTCAGTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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