Basic Information
VIS ID
TVIS44016647
Fusion event
HTLV-1-MMUT integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
49423844/49456131 (Hg38)
End
49423844/49456131 (Hg38)
Orient
+
Location type
Exonic
Target gene
MMUT
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-615-3p ; hsa-mir-4776-3p ; hsa-mir-4715-3p ; hsa-mir-3064-3p ; hsa-mir-4753-3p ; hsa-mir-6749-3p ; hsa-mir-130b-5p ; hsa-mir-150-5p ; hsa-mir-186-3p ; hsa-mir-8063 ; hsa-mir-483-3p ; hsa-mir-216b-5p
Nearest miRNA
hsa-mir-10398/Upstream/4258361; hsa-mir-10524/Downstream/2688218;
Nearest TSS
ENST00000381078/Upstream/1387442; ENST00000335783/Downstream/7060;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1387237, chr6-CpG: 20/Downstream/7090
Upstream sequence
CTATGCATTTCTTAATGTTGAAACAATATCTAGGTTTAATTTACTCACCTTGGTGCAAATTCATCAATTGTCAGGCCAGCCTGGAGTCCAGTTCTAGAGT
Downstream sequence
ACTCCAATCCATCTGCTAAAGTATAGGCCAGCTCCAGAATGGCATCAGCCCCTGCTTCCTGCATATGGTATCCACTAATTGAAATTGAATTAAATTTTGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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