Basic Information
VIS ID
TVIS44016648
Fusion event
HTLV-1-EXOC2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p25.3
Reference genome
GRCh37/hg19
Start
511587/511587 (Hg38)
End
511587/511587 (Hg38)
Orient
-
Location type
Intronic
Target gene
EXOC2
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-615-3p ; hsa-mir-30d-5p ; hsa-mir-30a-5p ; hsa-mir-570-3p ; hsa-mir-5582-3p ; hsa-mir-548as-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-659-3p ; hsa-mir-607 ; hsa-mir-3671 ; hsa-mir-563 ; hsa-mir-380-5p ; hsa-mir-203a-3p ; hsa-mir-153-5p ; hsa-mir-1250-3p ; hsa-mir-7853-5p ; hsa-mir-105-5p ; hsa-mir-1252-3p
Nearest miRNA
hsa-mir-10398/Downstream/878727;
Nearest TSS
ENST00000381078/Upstream/118308; ENST00000430842/Downstream/12584;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/86760, chr6-CpG: 258/Downstream/7492
Upstream sequence
AGGAGACTAATTTTTGAATATGCCACACATCTGTTTAGATGGCTAAAACCACAAAGCACTGGCCTTGCACCCTGTTGGGACTGACGACATTGAAGTGTGA
Downstream sequence
GGCCAAGAGAGGGCTGCACGGGGGCATCTGGATTGAACCCAGCCCGAGCGGGACAAGCCGCTCACCTGCAGGGGCCTGCGTTTCTAAAGCTGCAAGGCCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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