Basic Information
VIS ID
TVIS44016652
Fusion event
HTLV-1-BEND6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
56871671/57006873 (Hg38)
End
56871671/57006873 (Hg38)
Orient
-
Location type
Intronic
Target gene
BEND6
miRNAs that regulate target gene
hsa-mir-1299 ; hsa-mir-6128 ; hsa-mir-875-3p ; hsa-mir-6870-3p ; hsa-mir-622 ; hsa-mir-892c-3p ; hsa-mir-4676-3p ; hsa-mir-452-5p
Nearest miRNA
hsa-mir-10398/Upstream/3729802; hsa-mir-10524/Downstream/383259;
Nearest TSS
ENST00000381078/Upstream/51501; ENST00000484701/Downstream/6936;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/51363, chr6-CpG: 73/Downstream/39531
Upstream sequence
atagccaaagcaattctgagcaaaaagaacaatgctggatgtatcactcaaatatactaccaagctgtaatagccaaagctgcatggtattggcttaaaa
Downstream sequence
acagacacattagaccaataggacagaatagagaactcagaaactaatccacataccgataatcaattgatttttgacaaaacaccaagaacattcactg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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