Basic Information
VIS ID
TVIS44016657
Fusion event
HTLV-1-EYS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q12
Reference genome
GRCh37/hg19
Start
64590733/63880840 (Hg38)
End
64590733/63880840 (Hg38)
Orient
+
Location type
Intronic
Target gene
EYS
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-510-3p ; hsa-mir-376a-5p ; hsa-mir-4680-5p ; hsa-mir-494-3p
Nearest miRNA
hsa-mir-10398/Upstream/6490628; hsa-mir-10524/Downstream/7496120;
Nearest TSS
ENST00000381078/Upstream/74004; ENST00000424274/Downstream/185536;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/244280, chr6-CpG: 22/Downstream/1420520
Upstream sequence
TAATTTCAGTTTTAAATACAAGAGGCTGAAAGTGGCTTCAGGCTTTTTCAATTAAAAGATTTAGTTTGCAACTTCTTTGCACTGGAAAAGACTAAATCTC
Downstream sequence
TTGGAATCAGTTGACATGATGTTAAAATGGACTGTGCTATTTCTTTAAAAGCCATGTACAATGGCCATTTCTCATCAAAAGGTGTTTTGGCTGTAGGCAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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