Basic Information
VIS ID
TVIS44016670
Fusion event
HTLV-1-RIMS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q13
Reference genome
GRCh37/hg19
Start
72946041/72236338 (Hg38)
End
72946041/72236338 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6D
Target gene
RIMS1
Nearest miRNA
hsa-mir-10398/Upstream/832717; hsa-mir-10524/Downstream/731349;
Nearest TSS
ENST00000381078/Upstream/19578; ENST00000370420/Downstream/14076;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/53164, chr6-CpG: 174/Downstream/384876
Upstream sequence
TAAACATAGATTTTAAAATATTCTATAATAAAACTCAGACTTTGATAGTCTTATGGGCATAGATACATGTTTCAGATGAGATGGTCAGCTGCAGAGATGC
Downstream sequence
ATTTAGGCTATTAAGCTTTGCACAATGGTAAATTGCTTCCCAAAGGTGTCATTTTCTTGCTTTGAATCTACAGTCTTTATAGTCATAGACCTACATTTTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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