Basic Information
VIS ID
TVIS44016683
Fusion event
HTLV-1-MDN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q15
Reference genome
GRCh37/hg19
Start
90439310/89729591 (Hg38)
End
90439310/89729591 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6G
Target gene
MDN1
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-642a-5p ; hsa-mir-484 ; hsa-mir-186-5p ; hsa-mir-222-3p ; hsa-mir-92a-3p ; hsa-mir-1260b ; hsa-mir-6875-3p ; hsa-mir-3685 ; hsa-mir-155-3p ; hsa-mir-7848-3p ; hsa-mir-8485 ; hsa-mir-7153-5p ; hsa-mir-146b-5p ; hsa-mir-146a-5p ; hsa-mir-589-5p ; hsa-mir-362-3p ; hsa-mir-329-3p
Nearest miRNA
hsa-mir-10398/Upstream/11190282; hsa-mir-1202/Downstream/583151;
Nearest TSS
ENST00000381078/Upstream/56122; ENST00000547893/Downstream/90127;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/90746, chr6-CpG: 52/Downstream/89827
Upstream sequence
GTGTAAGCTAGGCATATGGGCCACATGGTTCCACATAATCAACTTCATCCAATGTTTTTGGCCACCAAAACAATTCACACTGTGTCCTTAACCTGTAAGT
Downstream sequence
TAACTGATATGCAGGACTAATAACAGTCTTGTAATATTTAACATTTGTGCCACTGTCTCTTGGAAGAAGtttttgttttgttttcgtttttttttttttt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate