Basic Information
VIS ID
TVIS44016688
Fusion event
HTLV-1-MANEA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q16.1
Reference genome
GRCh37/hg19
Start
96054983/95607107 (Hg38)
End
96054983/95607107 (Hg38)
Orient
-
Location type
UTR3
Target gene
MANEA
miRNAs that regulate target gene
hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-513a-5p ; hsa-mir-1468-3p ; hsa-mir-545-3p ; hsa-mir-205-3p ; hsa-mir-4461 ; hsa-mir-6876-5p ; hsa-mir-4476 ; hsa-mir-548p ; hsa-mir-6859-5p ; hsa-mir-3125 ; hsa-mir-3916 ; hsa-mir-3120-3p
Nearest miRNA
hsa-mir-10398/Upstream/4085370; hsa-mir-1202/Downstream/2417424;
Nearest TSS
ENST00000381078/Upstream/18885; ENST00000483933/Downstream/408877;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/28941, chr6-CpG: 26/Downstream/408886
Upstream sequence
tttaatttaattacataaattaaaCCTTACCATGACCAAATTGTGTTAGGACGGCCTGCTATCTACAGCACAGTGTGTCATTTGCAGATTTGTGGTTACC
Downstream sequence
TATACCACGCTAGGTGTTTTGACATGTTTAGTGTTTCTGCTTTACAGTGCTGAATTCCATATTTTAGAAGCTATGAAAGTCCTTTTATGAAAAAGTTACT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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